ERC Advanced Grant · 2021
How does a cell with unstable, complex genomic rearrangements stay alive, and even give rise to aggressive, highly resistant malignancies? This question remains an ultimate research challenge for cancers with highly aberrant genomes, such as acute myeloid leukemia with complex karyotype (CK-AML). Its etiology, time-resolved clonal dynamics, molecular heterogeneity, and treatment resistance mechanisms are still largely elusive. In particular, the genetic and non-genetic dynamics that drive cancer progression under treatment are elusive to current technologies and escape single-cell resolution. SHATTER-AML will tackle the genomic enigma of CK-AML by analyzing longitudinally obtained…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.