ERC Advanced Grant · 2021
Microglia As conTroller of braIn metaboLism During Aging
Microglia represent the main brain residential immune cells. In the last years evidence emerged that, besides representing the first line of defense against pathogenic insults, microglia are also centrally involved in physiological functions essential for correct CNS development and function. Microglia, in a spatially and temporally controlled manner, influence neuronal apoptosis, neurogenesis and myelin formation and manage synapse homeostasis, including removing supernumerary synapses during development. These widely heterogeneous roles are supported by distinct subtypes -or states- of microglia, present in different regions of the brain and at different times during CNS development. In…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.