ERC Consolidator Grant · 2021
Organ and mutation dependencies shaping the tumor microenvironment
Tumors are ecosystems in which cancer cells interact with diverse cell populations. In each such ecosystem, environmental conditions, cellular compositions and paracrine signaling create a distinct tumor habitat. How much the composition of the habitat is dictated by the organ versus specific mutations in the cancer cells is unknown. If different organs and mutations have common microenvironmental design principles, one could devise more general therapy. Otherwise, therapy must be mutation and organ specific. To approach this, we will focus on major cancer mutations – in BRCA1/2 – and on the four organs where BRCA mutations drive cancer: breast, ovary, pancreas and prostate. We will dissect…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.