ERC Starting Grant · 2021
The function of B cells in myocardial infarction-accelerated atherosclerosis
Survivors of acute myocardial infarction (MI) are at a particularly high risk for accelerated atherosclerosis and recurrent atherothromobosis. Nevertheless, mechanistic preclinical studies in atherosclerosis research world-wide are typically conducted in unchallenged (without MI) atherosclerosis-prone mice and thus do not address the specific pathophysiology of post-MI atherosclerotic cardiovascular disease. We conducted a single-cell RNA sequencing coupled to B cell receptor (BCR) sequencing analysis of sorted CD45+ splenocytes from atherosclerosis-prone mice that were fed an atherogenic diet for eight weeks in total and were subjected four weeks after the initiation of the atherogenic…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.