Carvalho-Santos Lab

Research focus

ERC Starting Grant · 2021

The impact of germline metabolic reprogramming on reproduction and physiology

Animals are composed of multiple tissues with different metabolic needs. During differentiation, the establishment of specific metabolic programs allows cells to acquire specialized functions. The nutrients that fuel these cell-specific metabolic pathways are obtained via the diet. In order to secure proper nutrient supply to these tissues, the central nervous system accesses their metabolic states, allowing the animal to mount behavioral strategies to adapt nutrient appetite. Our understanding of how cell-specific metabolic programs regulate animal physiology and behavior has been hindered by the lack of tractable experimental systems. Using Drosophila melanogaster I uncovered that the…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.