ERC Starting Grant · 2021
Dissecting the impact of epithelial stem cell niches on oral cancer heterogeneity
The oral epithelium is a unique tissue with a high degree of structural heterogeneity and distinct microenvironments (niches). However, the molecular mechanisms underlying the site-specific proliferation and differentiation of oral epithelial stem cells (OESCs) remain poorly understood. Oral squamous cell carcinoma (OSCC), one of the most common oral cancers, is a heterogeneous cancer type. Occurrences of metastatic lesions and treatment response differ from oral site to site, indicating a causal link to the heterogeneous nature of distinct OESC pools. In the OralNiche project, we will for the first time systematically and comprehensively characterise the OESC pools, dissect key mechanisms…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.