Deelen Lab

Leiden University Medical Center

West-Nederland (NL3) · Netherlands

ERC-funded
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ERC Starting Grant · 2021

Elucidating and targeting the mechanisms encoded in the genome of long-lived individuals to improve healthy ageing

Advancing age is the major risk factor for many serious illnesses, including cancer, cardiovascular disease, and dementia. The rising number of older individuals is thus causing a major burden of ill health. However, individuals that reach an exceptional old age often seem to escape or delay age-related diseases, and part of this trait seems to be encoded in their genome. Hence, by studying the genome of long-lived individuals, we may be able to identify mechanisms that could be targeted for healthy ageing in the general population. My previous work suggests that large genome-wide association studies (GWAS) of long-lived individuals can be used to identify genetic variants involved in…

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