ERC Advanced Grant · 2022
Intestinal Gluconeogenesis: Emerging Regulator of Energy Homeostasis
Obesity and type 2 diabetes continuously progress worldwide, compromising healthy aging. Deregulated endogenous glucose production (EGP) is involved in hyperglycemia and its complications. Among the 3 organs (liver, kidney, intestine) contributing to EGP, I uncovered with my team that intestinal gluconeogenesis (IGN) has the capacity to interfere in the control of energy homeostasis. Indeed, intestinal glucose initiates a gut-brain circuit controlling both body weight and glucose production by the liver, the strongest quantitative contributor to EGP. Intestinal gluconeogenesis is, thus, a novel target to control obesity and diabetes. The IGN project has 3 objectives: Understand: is…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Centre for Scientific Research (CNRS)