ERC Advanced Grant · 2022
Healthy Microbiota Avoiding Fractures during Ageing
The basic research problem: Gradual loss of bone and muscle mass with ageing leads to increased risk of fractures in the elderly population. There is a large medical need for new fracture preventive therapies with minimal side effects and novel biomarkers that improve the prediction of fracture risk. The aim of the proposed research is to test our hypothesis that the increased fracture risk in elderly people is caused by an age-dependent unhealthy change of the gut microbiota (GM) composition, resulting in reduced bone and muscle mass, and thereby increased fracture risk. Methodology: We will identify age-dependent GM signatures that are causally associated with reduced bone and muscle mass…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.