ERC Advanced Grant · 2022
Dissecting the Brain Basis of Obesity-Induced Pubertal Alterations: A View to a Kiss
Child obesity is a worrying condition, affecting 20% adolescents. Among its comorbidities, early obesity is linked to disturbed puberty, which is more evident in girls, but bound to adverse health outcomes in both sexes. Yet, how our brain decodes nutritional info to finely control puberty remains unsolved. Genetic data suggest obesity is largely an hypothalamic disease. Puberty is also hypothalamic-driven and governed by complex neuronal circuits. Among them, Kiss1 neurons have emerged as key elements in the brain control of puberty and its metabolic regulation, likely in cooperation with other central signaling systems, as POMC/melanocortins. Yet, the mechanisms whereby early obesity…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.