ERC Advanced Grant · 2022
CHARTING THE TOKEN OF TIME: YAP/TAZ TRANSCRIPTIONAL REGULATORS AT THE ROOTS OF AGING
A major challenge in aging research is to distinguish which age-related alterations play a driving role and their interconnections. Aging ultimately implies dysregulated transcription; yet, the identity of signaling cascades and transcription factors that control youthfulness and aging in adult tissues remains poorly understood. Aging also entails maladaptive changes in how cells communicate with each other and their surrounding extracellular matrix (ECM). Senolytics approaches have revealed the role of senescent cells as drivers of aging, leaving however unclear what cell types first become senescent in real tissue and why. Here, we aim to address and connect these fundamental unknowns…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.