ERC Consolidator Grant · 2022
Hibernation timing to reveal mechanisms of rheostasis
HiTime is a project about the adjustment of homeostatic set points in physiology. This is known as rheostasis and is of core importance for transitions between physiological states. I seek to develop the concept that a specialised cell type in the hypothalamus, the tanycyte, is the cellular embodiment of a rheostat, and that by understanding the function of the tanycyte, we will gain fundamental insights into hypothalamic control of rheostasis. Since rheostasis is weak in laboratory mice bred to live in constant laboratory environments, new paradigms must be developed. I will therefore investigate tanycyte function in the context of seasonal deep hibernation: the most dramatic example of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.