ERC Consolidator Grant · 2022
The Glucocorticoid Receptor in Aging and Circadian Endocrinology
The pandemic is stressful for many. In response to stress, glucocorticoids are released. They play essential roles as endogenous hormones and clinically as drugs. High levels are associated with cardiometabolic disorders and with aging. In contrast, diets like caloric restriction ameliorate metabolic dysfunction and prolong lifespan. These diets, however, also increase glucocorticoids. Now the open question is: What are the molecular and physiological effects of increased hormone levels, and are these diets beneficial because or in spite of elevated glucocorticoids? We recently found that nutrition reprograms glucocorticoid responses independently of the hormone level and that diurnal…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.