ERC Starting Grant · 2022
Decoding mitochondrial selective autophagy in synaptic homeostasis during ageing
Age-dependent accumulation of damaged mitochondria and synaptic loss represent early pathological hallmarks of brain ageing leading to neuronal death. Mitochondria-selective autophagy (mitophagy) is triggered to eliminate defective organelles promoting cellular and organismal survival. Mitophagy declines with age, while its induction extends lifespan and confers neuroprotection across diverse species. Although the pivotal role of mitophagy in neuronal physiology is steadily emerging, its contribution to synaptic homeostasis remains elusive. Building on our previous pioneering studies, SynaptoMitophagy aims to reveal the molecular underpinnings of age-dependent synaptic impairment, focusing…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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