ERC Starting Grant · 2022
Targeting the Metabolic Dependencies of Metastatic Tumor Cells
Metastasis is responsible for over 90% of deaths that occur in patients with cancer. So far there are no therapies that precisely target a metastatic disease due to the limited number of efficient druggable targets. Recently, I discovered in melanoma: circulating tumor cells are depending on arginine for their survival. In addition, I revealed that liver metastases specifically upregulate their alanine metabolism during metastasis. Thus, metastatic cells at different stages have dependencies on unique amino acids (AA). While most research focuses on the primary stage, my proposal will focus on the missing gap aiming to prevent metastases formation. Based on these new paradigm-changing…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.