Kroon Lab

Research focus

ERC Starting Grant · 2022

Endothelial metabolism dictates the bone marrow niche and the plaque microenvironment

Inflammation is an important driver of atherosclerosis, the primary cause of global morbidity and mortality in emerging and developed countries. New strategies to reduce atherosclerotic cardiovascular disease (CVD) risk are therefore eagerly needed. I recently found that atherogenic inflammatory stimuli rewire cellular metabolism in endothelial cells (ECs) and thereby contribute to atherosclerosis progression. Defining the intricate link between EC inflammation, metabolic rewiring and functional consequences for the vasculature will open new avenues for therapeutic strategies in CVD. My recent work shows that CVD-associated metabolic changes in ECs can affect their secretome. In turn, the…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.