Harel Lab

Hebrew University of Jerusalem

- · Israel

ERC-funded
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ERC Starting Grant · 2022

Genetic Design of Biological Time in Fish

Every species experiences a unique pace-of-life, which determines the duration of its embryonic development, onset of puberty, and rate of aging. However, how these traits are scaled so differently between species is largely unknown. Here, I propose to develop the tools to systematically study how the pace of life is regulated in vertebrates. To date, progress in our understanding has been experimentally hindered by the relatively long lifespans of classical vertebrate models. To address this challenge, I recently pioneered a genetic platform for rapid exploration of aging in the naturally short-lived turquoise killifish. Killifish species display up to 10-fold differences in their…

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