ERC Advanced Grant · 2023
A Novel Glutamine (Q) Sensory Role for Primary Cilia: Implications for Health and Disease
Primary cilia are single, microtubule-based, organelles protruding as antennae at the surface of most cells. Their dysfunction is associated with several genetic disorders, called the ciliopathies. We recently identified a new, previously undescribed, role for primary cilia as sensors of cellular nutrient availability. In this novel mTORC1-independent pathway, cilia directly communicate with mitochondria to drive metabolic reprogramming under nutrient stress, when glutamine (Q) becomes an obligated carbon source. Here, we will tackle two fundamental questions: i. why mammalian cells “taste” the extracellular milieu via a sensory monocilium, and how is the resulting information conveyed to…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.