Brüning Lab

Max Planck Society

Bayern (DE2) · Germany

ERC-funded
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ERC Advanced Grant · 2023

Deconstructing Hypothalamic Neurocircuitry Architecture and Function in Metabolic Control during Health and Disease

Understanding the exact nature of CNS-dependent regulation of body weight has become of utmost societal importance as we are witnessing an ever-increasing number of overweight and obese subjects who exhibit a predisposition for a plethora of obesity-associated diseases such as type 2 diabetes mellitus, cardiovascular diseases, and certain types of cancers. However, despite the tremendous advances made in defining the neurocircuitry basis underlying the central control of feeding and metabolism, critical open questions still remain. For example, how can we reliably identify the exact anatomical localization of the recently identified molecularly heterogenous cell types in the hypothalamus?…

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