ERC Consolidator Grant · 2023
Understanding malignant transformation of precancerous lesions in human colon
A crucial milestone in tumor progression is the transformation from a benign adenoma to a malignant cancer, which has profound impact on clinical outcome and therapy design. Despite its importance, it is poorly understood why it manifests itself as a bottleneck that can restrain precancerous adenomas for years. While recent sequencing efforts inform ‘static’ insights into the status of cancer genomes, these are incomplete to infer how they evolved, assess functional consequence of mutations, nor how much malignancy is environmentally instructed. Practical limitations hamper scientific advancement into the dynamic nature of tumor evolution. Foremost, studying human tumor evolution is…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.