Gaudenzio Lab

National Institute of Health and Medical Research (INSERM)

Ile-de-France (FR1) · France

ERC-funded
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ERC Consolidator Grant · 2023

Role of prenatal stress-induced fetal neuro-immune rewiring in susceptibility to develop pediatric eczema

The prenatal period is a critical timeframe during which all the physiological systems of the body, including immune and sensory systems, develop their specific functions and adapt to possible incoming cues. Atopic dermatitis, also known as “eczema”, is the most common skin manifestation in infants and toddlers from 3 months to 2 years of age, with a very early onset during the first years of life. While genetic and immune factors play an important role, recent epidemiological studies have listed prenatal stress as an important risk factor of allergic disorders, and associated prolonged exposure to high emotional strain during pregnancy to an increase in the offspring susceptibility to…

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