ERC Consolidator Grant · 2023
Altered brain-periphery crosstalk as a key pathomechanism for high-risk phenotypes in humans
Diabetes is a leading cause for morbidity and mortality worldwide. In our fight against the diabetes pandemic, my team and I recently identified subgroups of humans that are predictive for future life-threatening complications even before diabetes onset. Classification into these new risk groups is currently purely based on extensive phenotyping, yet, the underlying mechanisms are unclear. Of note, phenotypes of very high-risk persons are highly reminiscent of those from subjects with altered periphery-brain communication. I will combine ground-breaking experimental research in humans with latest data analysis approaches to delineate the causal relationship between altered brain-periphery…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.