ERC Starting Grant · 2023
PLASTicity of Endothelial Cell as new Target for acute myeloId leukemia TherapY
Acute myeloid leukemias (AML) are aggressive blood cancers with poor overall prognosis. The main intervention line is high-dose chemotherapy, often associated with resistance, relapse and long-term side effects. Although predominantly considered as genetic diseases of the hematopoietic system, AML also affect the bone marrow (BM) microenvironment, which contributes to disease pathogenesis. Particularly, we have revealed a thorough remodeling of the vascular tree, with endothelial cells (ECs) displaying dismantled junctions and an embryonic-like molecular signature. Our research hypothesis is that this embryonic-like ECs (E-ECs)– displaying a high grade of plasticity – are progressively…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Institute of Health and Medical Research (INSERM)