Gabanyi Lab

Gulbenkian Institute for Molecular Medicine (GIMM)

Continente (PT1) · Portugal

ERC-funded
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ERC Starting Grant · 2023

Trafficking mechanisms and physiological factors mediating a direct gut microbiota-brain neuron interaction

The gut-brain axis has emerged as a complex regulator of system-wide physiology, playing essential roles to maintain homeostasis, including contributions to brain development and activity, affecting host metabolism and behavior. The gut bacterial composition constantly fluctuates, allowing for the regular release of diverse microbe-derived compounds into the bloodstream. Although it is known that many gut-bacterial metabolites affect distant organs such as the brain, their direct interaction with brain neurons is rarely demonstrated. The impact of microbial metabolites on brain mechanisms are generally thought to be indirect due to interaction with, for example, the immune system or the…

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