ERC Starting Grant · 2023
Co-option of host circadian rhythms in cancer
Circadian rhythms (CRs) are the biological response to the periodic rotations of the Earth, and allow fundamental adaptations of organisms to a changing environment. CRs are molecularly controlled in every cell by a set of transcriptional factors that control, and are influenced by, core biological processes including metabolic, immune, and proliferative. My previous studies established, for the first time, that innate immune cells regulate the circadian physiology of tissues, including the susceptibility of the lung to be metastasized. In INN-TIME, I ask the reciprocal question to reveal if tumors take advantage of, and subvert, CRs of the innate (immune and stroma) compartments to escape…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.