ERC Starting Grant · 2023
Unraveling pacemaker (dys)function using novel stem cell-derived human heart models
The pacemaker cells of the sinoatrial node (SAN) trigger three billion heartbeats in an average human life span. At the start of each beat, the SAN must generate enough current to drive the surrounding atrial tissue, which contains 10,000 times as many cells as the SAN itself. This extraordinary biological feat is a result of intrinsic features such as SAN tissue architecture. In addition, SAN function is modulated by extrinsic inputs from the autonomic nervous system, which adjusts the pace from beat-to-beat, for example during exercise. Any disturbances to these core activities result in SAN dysfunction, which include abnormal heart rate (brady or tachycardias), SAN exit block (lack of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at Free University Medical Center Amsterdam (VUmc)