ERC Advanced Grant · 2024
Remodelling processes associated with genetic and non-genetic cardiac diseases can cause electrical conduction disturbances and arrhythmias. Current models used to predict functional alterations due to structural remodelling fail to accurately assess arrhythmogenic risk, mainly because they do not draw upon comprehensive functional and structural data and are typically based on low-resolution and non-integrated information. Here, I present HeartCORE, an interdisciplinary approach designed to establish a mechanistic relationship between electrophysiological dysfunction and structural alterations in an animal model that mimics human cardiac electrophysiology. Langendorff-perfused rabbit…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.