ERC Consolidator Grant · 2024
The Tipping Point from Genome Instability to Cancer
Cancer starts years to decades before diagnosis. Yet, early stages of tumor development are poorly understood. In particular, the precancer landscape of chromosome instability (CIN) is understudied, due to the scarcity of precursor lesions and methods to analyze CIN in single cells. The research presented here will address how the instability rate of the genome, followed by selection, determines whether a CIN-driven tumor arises. I hypothesize that the onset of CIN is the tipping point that governs the fate of a precancer clone. Using spatially aware and single-cell multiome methods that we developed, we will dissect essential factors that lead to malignancy via CIN, including…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.