ERC Consolidator Grant · 2024
Understanding Diagnosing and Early intervention in the Myeloid malignancy Continuum
As humans age, Hematopoietic Stem and Progenitor Cells (HSPCs) accumulate preleukemic mutations (pLMs), forming preleukemic HSPCs (preL-HSPCs) and leading to clonal hematopoiesis (CH). While the link between CH and myeloid malignancies is established, predicting progression remains elusive. The Shlush lab aims to enhance myeloid malignancies outcomes through early diagnosis and treatment. Still, it faces three gaps: 1) lacking advanced tools for diagnosis/risk stratification beyond mutations, 2) insufficient understanding of pLMs functional consequences, and 3) absence of targeted therapies against pLMs. To address these challenges, our proposed specific aims are as follows: Aim 1: Develop…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.