ERC Consolidator Grant · 2024
Peptide-drug conjugates for weight loss maintenance
The worldwide rise in obesity rates is causing significant harm to human health. While effective weight loss therapies are emerging, the challenge of maintaining weight loss remains unresolved. Having identified hunger-promoting Agouti-related protein (AgRP) neurons in the hypothalamus as drivers of weight recidivism, I will meet this challenge. With this project, I will leverage my profound expertise in drug development to engineer novel peptide-drug conjugates designed to obstruct AgRP-governed homeostatic weight regain in a cell specific fashion. In the food deprived state, AgRP neurons undergo structural changes that increases excitability and thus drives homeostatic weight regain. This…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.