ERC Consolidator Grant · 2024
During pregnancy, the cervix undergoes dramatic remodelling characterised by the emergence of mucus secreting goblet cells (GCs) that generate a cervical mucus plug (CMP) in the cervical canal. The CMP is thought to act as a barrier that is crucial for maintaining uterine sterility, thereby protecting the foetus from ascending bacterial infections. However, this view is based on relatively little experimental evidence and our knowledge of specific endogenous or exogenous factors that may regulate cervical GC functions and CMP properties is virtually non-existent. This knowledge gap has significant clinical implications, as preterm birth is a common consequence of intrauterine bacterial…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.