Dupin Lab

Research and Higher-Education Pole University of Bordeaux

Nouvelle-Aquitaine (FRI) · France

ERC-funded
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ERC Consolidator Grant · 2024

Unveiling lung resilience mechanisms: a ground-breaking way to cope with air pollution

Air pollution, exacerbated by heatwaves and wildfires, affects primarily the lungs, leading to potentially life-threatening effects eluding conventional treatments. In response, KINTSUGI adopts a new perspective by exploring lung resilience mechanisms, to understand how respiratory health is maintained in most individuals: drawing on evidence from both a broad evolutionary standpoint, where humans have evolved in environments exposed to particles and proofs of lung resilience observed particularly in smokers, it seeks to redefine the paradigm of investigating lung response to particulate pollution. For that, KINTSUGI focuses on the airway submucosal gland (SMG), an ectodermal appendage…

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