ERC Consolidator Grant · 2024
Unmasking Non-Genetic Determinants Instructing Tumor Initiation (IGNITE)
The gene-environment interaction paradigm has long provided a framework for understanding the contribution of environmental cues to cancer initiation. However, recent perspectives reveal that even amongst genetically identical cells, responses to environmental variation can be remarkably diverse. When and how pathogenic gene-environment interactions effectively ignite cancer remains ambiguous. IGNITE aims to explain what drives cancer initiation beyond genetics by dissecting (mal)adaptive responses to environmental variation at the cell, tissue, and organismal level, taking inflammation-driven pancreatic cancer as a disease paradigm. I hypothesize that qualitatively distinct forms of local…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at Institute for Research in Biomedicine Barcelona