ERC Starting Grant · 2024
ChECMating cellular senescence by modulating the surrounding matrisome
The increasing elderly population poses a dual challenge to the viability of both global health and our current welfare systems. One of the pivotal aspects of aging involves the accumulation of damaged cells, known as senescent cells, in organs. While these cells play a role in coordinating tissue repair whenever damage occurs, their aberrant accumulation disturbs normal tissue function, resulting in an unbearable burden that ultimately leads to aging. Understanding how these cells accumulate within the organism, a yet unresolved question, would offer invaluable insights into the aging process. We have recently reported that damaged cells rely on Integrins, a family of membrane proteins, to…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.