Laisk Lab

University of Tartu

Eesti (EE0) · Estonia

ERC-funded
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Research focus

ERC Consolidator Grant · 2025

Understanding Women’s Health Through the Lens of Hormonal Sensitivity: Genetics, Mechanisms and Health Trajectories

Hormonal sensitivity conditions such as premenstrual syndrome, hormonal medication side effects, and (peri)menopausal symptoms affect billions of women but remain poorly understood. These conditions share a common factor: fluctuations in estrogen and progesterone levels that interact with endocrine, neurological, and metabolic systems, creating a continuum of individual hormone sensitivity. UNDERwHER aims to redefine the hormone sensitivity spectrum (HSS) by addressing its biological underpinnings and health impact. UNDERwHER builds on the applicant's recent work on 42 female reproductive health phenotypes, which demonstrated the value of genetics in understanding women’s health. By…

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