ERC Consolidator Grant · 2025
BET Proteins in Early Life Stress-induced Cardiovascular Disease
Early life stress (ELS) in childhood due to physical or sexual violence, parental neglect, or trauma has been recently associated with an increased risk of cardiovascular disease in later life. However, the mechanisms linking ELS to cardiovascular impairment remain unexplored. Epigenetic regulation of gene expression is emerging as a pivotal process linking environmental exposure to disease phenotypes. Among chromatin remodelers, BET (bromodomain and extra-terminal) proteins are key regulators of gene transcription through their binding to acetylated lysine residues on histone tails via tandem bromodomains. Own preliminary data suggest that BET proteins are heavily involved in…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.