ERC Starting Grant · 2025
DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation
A quiescent, resilient layer of blood vessel-lining endothelial cells (ECs) is vital for maintaining organ function and enabling healthy aging. Much has been learnt in recent years about the mechanisms controlling the resilient EC phenotype. In turn, little is known if and how mechanisms of vascular resilience are affected by environmental rhythmic stimuli (extrinsic (e.g., light-dark, feeding-fasting) or intrinsic (e.g., blood pressure, hematopoiesis)). Performing day/night analyses of mouse liver and lung ECs, we identified distinct organ-specific time-of-the-day dependent transcriptomic programs of resting ECs. These translated functionally into temporal vascular adaptations during the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.