ERC Starting Grant · 2025
Spatial heterogeneity of tumor and CD8+ T cell metabolism in liver metastasis
While immune-based therapies targeting CD8+ T cells have transformed melanoma treatment, many patients still show inconsistent responses between primary tumors and metastases, particularly in the liver. CD8+ T cells face unique barriers in liver metastases, hindering their infiltration and suppressing their function. Recent studies show that CD8+ T cells adapt their metabolism based on the nutrients available in the tumor environment, and this metabolic adjustment plays a key role in their ability to fight cancer. Liver metastases have traditionally been studied as uniform in CD8+ T cell activity and metabolism; however, our findings reveal that each metastasis creates a distinct metabolic…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.