ERC Starting Grant · 2025
SINGle-cell mapping of Living kidney donation for the Assessment of Renal adaptation
>850 million people are affected by kidney disease, which is caused by kidney injury. Following injury, kidney cells have a remarkable ability to adapt. Previous studies have largely focused on kidney injury signatures, yet treatments successfully targeting injury in animals have failed in humans. Studies focused not on injury but on adaptation are lacking. The main reason for this is that studying kidney adaptation with existing methods is challenging due to the low signal-to-noise ratio of adaptation in the presence of injury. Instead of studying adaptation in kidney injury patients, SINGuLAR will therefore study isolated adaptation in living kidney donors: Donors, who irreversibly lose…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.