ERC Starting Grant · 2025
Vascular determinants of cancer cell fate and immune regulation in brain metastasis
Brain metastasis (BrM) is one of the deadliest cancer complications, affecting 30-40% of patients. When cancer cells migrate from the primary tumor to the brain, they face the critical challenge of adapting to an entirely new microenvironment. This includes various tissue-resident cell types, a distinct extracellular matrix composition, and more importantly, the challenge of traversing the multiple layers constituting the blood-brain barrier (BBB). The BBB – composed of the endothelial cells, mural cells, and associated microglia and neurons – not only serves as the initial gateway for cancer cells during the early stages of metastatic colonization but also for recruited immune cells, such…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.