VUB - Free University of Brussels
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest (BE1) · Belgium
ERC Starting Grant · 2025
IRON-BETA - Unraveling the iron metabolism of pancreatic β-cells
Iron is a critical cofactor for proteins and enzymes involved in oxygen and energy metabolism, functions that are especially vital in pancreatic β-cells. In these cells, iron is indispensable for mitochondrial respiration, the process that powers insulin production. However, disruptions in iron homeostasis - whether through deficiency or overload - have been linked to β-cell dysfunction, yet the underlying mechanisms remain poorly understood. With IRON-BETA, I seek to unravel how iron metabolism regulates β-cell identity, function, and survival, under both normal and stressed conditions, such as type 2 diabetes (T2D) and early post-transplant ischemia. Using cutting-edge techniques and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.