ERC Starting Grant · 2025
Circadian system ageing in cancer: from tumourigenesis to treatment
Age is cancers primary risk factor and a significant determinant of how the resulting disease presents and progresses. Yet the specific contribution of ageing’s diverse hallmarks to this phenomenon is poorly defined. Circadian rhythms are a conserved adaptation that enables organisms to anticipate daily environmental cycles and thus mitigate their harmful effects on the body. However, in recent years, a decay of homeostatic cellular, tissue and systemic circadian rhythms has emerged as a hallmark of mammalian ageing. Concurrently, in the context of cancer, circadian inputs from the host are known to drive daily rhythms in tumour microenvironment composition, metastasis seeding and treatment…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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