Tanaka Lab

Research Institute of Molecular Pathology - Vienna

Ostösterreich (AT1) · Austria

ERC-funded
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ERC Advanced Grant · 2016

Understanding the evolution of regeneration-permissive gene expression and positional memory in Axolotl limb regeneration

Molecular studies of development in diverse animal models have revealed the remarkably conserved set of morphogens governing growth and patterning of body axes and organ fields. Equally astounding is the diversity of form and function arising from the implementation of these morphogens. The systematic analysis of well-defined traits in closely related species has revealed how changes in gene regulatory sequences and their trans-acting factors have yielded diversity. An important future challenge is to understand, at the genome level, the evolution of animal form in situations where such a rich set of closely related species may not be available. Vertebrate limb regeneration is a…

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