ERC Starting Grant · 2016
How to build a brain? Engineering molecular systems for mechanosensation and -protection in neurons
Mechanical forces are ubiquitous signals that provide critical and dynamic information about the environments around cells and organisms. Signals about touch, sound, and movements are transmitted to specialized mechanoreceptors but also deform the neuronal cytoskeleton of the central nervous system, particularly when strong forces are involved. Although failures to sense and cope with stresses are linked to human diseases including peripheral neuropathies and dementias, little is known about the connections between biomechanics and disease. A major reason for this gap is the technical challenge of detecting forces and deformations within a living cell or organism. Given the poor prognosis…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.