ERC Advanced Grant · 2017
Sex differences in intestinal plasticity
Sex differences in intestinal plasticity Males and females often differ in their physiology and disease susceptibility. Sex hormones play key roles in sculpting and maintaining such sex differences, but increasing evidence points to a contribution of cell-intrinsic mechanisms. We are only beginning to understand the molecular mediators of these intrinsic mechanisms, and little is known about the organs where they function and their effects at the whole-organism level. Our work in flies recently revealed the existence of intrinsic sex differences in intestinal stem cell proliferation. This work raised the possibility that other, more metabolically significant intestinal cell types have their…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.