ERC Advanced Grant · 2017
Cells face a phosphate challenge. Growth requires a minimal concentration of this limiting resource because intracellular phosphate (Pi) is a compound of nucleic acids and modifies most cellular proteins. At the same time, cytosolic Pi may not rise much, because elevated cytosolic Pi can stall metabolism. It reduces the free energy that nucleotide triphosphate hydrolysis can provide to drive energetically unfavorable reactions. I will undertake a pioneering study to elucidate how cells strike this critical balance. We will identify a novel pathway for intracellular phosphate reception and signaling (INPHORS) and explore the role of acidocalcisomes in it. These studies may identify a key…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.