ERC Consolidator Grant · 2017
Epithelial polarity is one of the most fundamental types of cellular organization, and correct cellular polarization is vital for all epithelial tissue. Failure to establish polarity leads to severe phenotypes, from catastrophic developmental deficiencies to life-threatening diseases such as cancer. Despite knowing much about the signalling and trafficking machinery vital for polarity, we lack quantitative knowledge about the intracellular mechanical processes which organize and stabilize epithelial polarity. This presents a critical knowledge gap, as any elaborated understanding of intracellular organization needs to include the forces and viscoelastic mechanical properties that position…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.