Dumont Lab

Research focus

ERC Consolidator Grant · 2018

Canonical and Non-canonical modes of Chromosome Segregation in Oocyte Meiosis

Cell division is crucial for the development of complex organisms, for the homeostasis of tissues, and for the reproductive capacity of individuals. While most somatic cells are diploid and proliferate through mitosis, multiplication of sexually reproducing species relies on haploid gametes that are generated through a specialized cell division process called meiosis. To achieve this reduction in ploidy, two rounds of chromosome segregation follow a single phase of genome replication. Inaccuracy in this process leads to gametes that carry an incorrect number of chromosomes and to aneuploid embryos after fertilization. In their vast majority, these are non-viable and lead to spontaneous…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.