ERC Starting Grant · 2018
Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system
Neurons employ cell-specific gene regulatory mechanisms. One particularly striking process is the recently discovered, drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes, which occurs in neurons from flies to humans. The function of the resulting ultra-long 3’ UTRs is unknown. RNA deregulation plays a central role in neurological diseases; to understand underlying causes, it is essential to study regulatory processes and define the function of these novel 3’ UTRs. In Drosophila, the neuronal RNA-binding protein ELAV is the main effector of nervous system specific 3’ UTR extension. ELAV’s association with the promoter region of its target genes is required for…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.