ERC Advanced Grant · 2021
Sculpting circuits and behavior by developmental neuronal remodeling
Neuronal remodeling is a conserved strategy to refine neural circuits during development. Defects in remodeling have been associated with neuropsychiatric disorders, but direct mechanistic causality is lacking. Despite its fundamental significance, how remodeling of neuronal processes affects circuit architecture and function, and how this ultimately shapes behavior, is not only unknown, but also extremely challenging to study in complex organisms. Our lab is a world-leader in the molecular mechanisms of neuronal remodeling. We use the stereotypic remodeling of the Drosophila Mushroom Body (MB), a complex circuit within the fly brain, as powerful genetic model to study this question.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.